Sleep is essential for health, yet nearly 40% of adults report falling asleep unintentionally during the day, and one-third sleep less than seven hours nightly (Blackwelder et al., 2021; National Heart, Lung, and Blood Institute [NHLBI], 2022; American Academy of Sleep Medicine, 2015). Sleep deprivation is linked to poor decision-making, depression, heart disease, and obesity. Major contributors include stress, which activates the HPA axis (Kviatkovsky et al., 2023), aging (Ly & Naidoo, 2019), chronic pain (Duo et al., 2023), and disruptions to the endocannabinoid system (Lavender et al., 2022).

Cannabidiol (CBD) has been shown to improve sleep, reduce stress, and support healthy pain responses (Carlini & Cunha, 1981; Shannon et al., 2019). CBD significantly reduced anxiety in public speaking tests (Linares et al., 2019; Bergamaschi et al., 2011) and helped chronic pain patients reduce opioid use (Capano et al., 2020). TruEase PM enhances CBD absorption with VESIsorb® technology, making it 4.4 times more bioavailable (Knaub et al., 2019).

Beta-caryophyllene (BCP) and melatonin also contribute, supporting healthy inflammatory responses and circadian rhythms (Scandiffio et al., 2020; Duffy et al., 2022). Together, TruEase PM offers a clinically backed solution for promoting restorative sleep and improving patient wellness.

American Academy of Sleep Medicine. (2015). Seven or more hours of sleep per night: A health necessity for adults. https://aasm.org/seven-or-more-hours-of-sleep-per-night-a-health-necessity-for-adults/

Bergamaschi, M. M., Queiroz, R. H., Chagas, M. H., de Oliveira, D. C. G., De Martinis, B. S., Kapczinski, F., ... & Crippa, J. A. (2011). Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients. Neuropsychopharmacology, 36(6), 1219–1226. https://doi.org/10.1038/npp.2011.6

Blackwelder, A., Hoskins, M., & Huber, L. (2021). Effect of inadequate sleep on frequent mental distress. Preventing Chronic Disease, 18, E61. https://doi.org/10.5888/pcd18.200548

Capano, A., Weaver, R., & Burkman, E. (2020). Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients: A prospective cohort study. Postgraduate Medicine, 132(1), 56–61. https://doi.org/10.1080/00325481.2019.1685298

Carlini, E. A., & Cunha, J. M. (1981). Hypnotic and antiepileptic effects of cannabidiol. Journal of Clinical Pharmacology, 21(S1), 417S–427S. https://doi.org/10.1002/j.1552-4604.1981.tb02625.x

Duffy, J. F., Wang, W., Ronda, J. M., & Czeisler, C. A. (2022). High dose melatonin increases sleep duration during nighttime and daytime sleep episodes in older adults. Journal of Pineal Research, 73(1), e12801. https://doi.org/10.1111/jpi.12801

Duo, L., Yu, X., Hu, R., Duan, X., Zhou, J., & Wang, K. (2023). Sleep disorders in chronic pain and its neurochemical mechanisms: A narrative review. Frontiers in Psychiatry, 14, 1157790. https://doi.org/10.3389/fpsyt.2023.1157790

Knaub, K., Sartorius, T., Dharsono, T., Wacker, R., Wilhelm, M., & Schön, C. (2019). A novel self-emulsifying drug delivery system (SEDDS) based on VESIsorb® formulation technology improving the oral bioavailability of cannabidiol in healthy subjects. Molecules, 24(16), 2967. https://doi.org/10.3390/molecules24162967

Kviatkovsky, S. A., Hickner, R. C., Cabre, H. E., Small, S. D., & Ormsbee, M. J. (2023). Collagen peptides supplementation improves function, pain, and physical and mental outcomes in active adults. Journal of the International Society of Sports Nutrition, 20(1), 2243252. https://doi.org/10.1186/s12970-023-00566-5

Lavender, I., McGregor, I. S., Suraev, A., Grunstein, R. R., & Hoyos, C. M. (2022). Cannabinoids, insomnia, and other sleep disorders. Chest, 162(2), 452–465. https://doi.org/10.1016/j.chest.2022.02.032

Linares, I. M., Zuardi, A. W., Pereira, L. C., Queiroz, R. H., Mechoulam, R., Guimarães, F. S., & Crippa, J. A. (2019). Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test. Brazilian Journal of Psychiatry, 41(1), 9–14. https://doi.org/10.1590/1516-4446-2017-0015

Ly, S., & Naidoo, N. (2019). Loss of DmGluRA exacerbates age-related sleep disruption and reduces lifespan. Neurobiology of Aging, 80, 83–90. https://doi.org/10.1016/j.neurobiolaging.2019.04.004

National Heart, Lung, and Blood Institute. (2022). What are sleep deprivation and deficiency? https://www.nhlbi.nih.gov/health/sleep-deprivation

Scandiffio, R., Geddo, F., Cottone, E., et al. (2020). Protective effects of (E)-β-caryophyllene (BCP) in chronic inflammation. Nutrients, 12(11), 3273. https://doi.org/10.3390/nu12113273

Shannon, S., Lewis, N., Lee, H., & Hughes, S. (2019). Cannabidiol in anxiety and sleep: A large case series. The Permanente Journal, 23, 18-041. https://doi.org/10.7812/TPP/18-041