TruGen3: A Legacy of Science-Driven Nutraceutical Innovation

In the highly competitive world of nutritional supplements, few companies embody the ideals of clinical precision, integrity, and innovation as well as TruGen3. Founded in 2016 by L. Douglas Lioon—former CEO of Douglas Laboratories—and his family, TruGen3 represents the culmination of three generations of excellence in the nutraceutical field.

The name, short for "3 Generations of Truth,” is no coincidence: it reflects the company’s commitment to scientific integrity, patient-focused results, and delivering truth in nutrition across generations continuing with his sons, S. Michael and L. Douglas Lioon Jr.

Today, TruGen3 continues to build a sterling reputation as a trusted provider of clinically formulated, doctor-designed, and evidence-backed supplements, available exclusively to healthcare professionals.

A Family Legacy Rooted in Clinical Excellence

TruGen3’s story begins long before its official founding. L. Douglas Lioon spent more than 30 years leading Douglas Laboratories, establishing it as a global leader in practitioner-exclusive supplements.

Under his stewardship, Douglas Laboratories became synonymous with pharmaceutical-grade manufacturing standards, clinical efficacy, and healthcare practitioner trust, serving over 15,000 medical professionals worldwide. Atrium Innovations acquired Douglas Labs in 2005.

With TruGen3, Lioon aimed to create something even more specialized—a highly curated supplement line focused on addressing specific clinical needs, formulated from the ground up with practitioner input and emerging science.

Importantly, TruGen3 operates with the philosophy that less is more: by offering a tightly controlled catalog of best-in-class products, they ensure every supplement meets their rigorous standards for quality, clinical relevance, and bioavailability.

Today, Lioon's vision is supported by a leadership team of industry veterans and medical advisors who share the mission to bring truth and transparency back to the practitioner supplement channel.

Doctor-Formulated, Science-Driven Innovation

Unlike mass-market supplement brands, TruGen3’s formulations are physician-designed and scientifically validated. Each product begins with a foundation of clinical evidence, patient needs, and real-world healthcare practitioner feedback.

Every step of the formulation process—from ingredient selection to delivery technology—is guided by a singular principle: Formulate supplements that truly move the needle for patient outcomes.

TruGen3’s development process incorporates:

• Review of published clinical trials on both individual ingredients and full formulations
  
• Ongoing collaboration with leading functional and integrative medicine physicians
  
• Prioritization of therapeutic dosing based on scientific evidence rather than marketing trends
  
• Commitment to "clean label" standards, eliminating unnecessary fillers, allergens, and additives wherever possible
  
  

Moreover, TruGen3’s unwavering focus on condition-specific support (e.g., inflammation modulation, cognitive function, healthy sleep, metabolic wellness) ensures that each product addresses key health needs with precision and potency.

Premium, Branded Ingredients for Maximum Bioavailability

In a crowded market filled with generic raw materials, TruGen3 distinguishes itself by using branded, clinically studied ingredients that offer superior quality and proven results.

One of TruGen3’s standout features is the use of VESIsorb®, a patented naturally self-assembling colloidal delivery system.

This technology dramatically enhances the absorption and bioavailability of fat-soluble nutrients such as cannabinoids, omega-3s, curcumin, and CoQ10.

Key Benefits of VESIsorb®:

• Increases solubility of poorly absorbed ingredients
• Provides consistent plasma concentrations
• Improves therapeutic effectiveness at lower doses

Formulation Philosophy: The TruGen3 Difference

At its core, TruGen3 is guided by a formulation philosophy built on five key pillars:

1. Scientific Integrity
2. Bioavailability: Patented delivery systems and enhanced absorption strategies ensure that active ingredients are utilized effectively by the body.
3. Only ingredients supported by robust, peer-reviewed research make it into TruGen3 formulationsClinical Relevance: Every product is formulated with input from practicing clinicians to address real-world patient needs.
4. Purity and Transparency: Raw materials are meticulously sourced and rigorously tested for identity, potency, and contaminants.
5. Targeted Innovation: Rather than flooding the market with hundreds of products, TruGen3 selectively offers formulations that demonstrate unique value and superior performance.

This approach ensures that TruGen3 supplements are not just products, but integral tools that empower healthcare providers to improve patient outcomes.

Commitment to Healthcare Professionals

From its inception, TruGen3 has committed to serving healthcare professionals exclusively. This practitioner-first approach means:

• Providing technical documentation and clinical trial summaries for every product
• Offering practitioner education and clinical integration support
• Creating patient-friendly educational materials to enhance compliance and engagement
  

TruGen3 also collaborates closely with functional medicine and integrative health communities, offering webinars, live events, and case-study collaborations to advance the field of nutritional medicine.

This focus on practitioner partnerships sets TruGen3 apart from retail brands that often prioritize volume over clinical value.

Product Highlights

TruGen3 offers a highly curated portfolio of supplements designed for clinical precision. Among its standout offerings are three advanced formulations that exemplify the brand’s commitment to scientific innovation, bioavailability, and cardiovascular support: VESInol-QH, TG3 Heart Support, and Qmega-TG3.

VESInol-QH™: Enhanced Absorption of Ubiquinol and Vitamin E

VESInol-QH™ is a specialized formulation delivering ubiquinol, the reduced and active antioxidant form of coenzyme Q10 (CoQ10), alongside delta- and gamma-tocotrienols, advanced members of the vitamin E family with potent antioxidant and cardiovascular benefits. This product utilizes VESIsorb® delivery technology, which significantly enhances the bioavailability of fat-soluble compounds like ubiquinol.

Key Features:

• VESIsorb® technology enables superior absorption and bioavailability compared to standard CoQ10 products.
• Contains ubiquinol, the body’s preferred form of CoQ10, essential for mitochondrial energy production and cardiac health.
• Includes tocotrienols to further support healthy lipid metabolism, oxidative balance, and cellular function.
• Clinically suitable for patients with cardiovascular disease, chronic fatigue, or statin-induced CoQ10 depletion.
• This formulation is ideal for supporting mitochondrial function, vascular health, and cellular energy, particularly in aging populations or those on statin medications.

TG3 Heart Support™: Comprehensive Cardiovascular Nutritional Therapy

TG3 Heart Support™ is a multi-ingredient formula designed to provide foundational and targeted support for cardiovascular function, blood pressure modulation, and vascular integrity. It combines key nutrients and botanicals—each selected based on evidence for synergistic heart health benefits.

Key Features:

• Contains grape seed extract and green tea polyphenols, both rich in antioxidants that help protect endothelial function and reduce oxidative stress.
• Includes magnesium and potassium, essential minerals for healthy blood pressure and cardiac rhythm.
• Features L-citrulline to promote nitric oxide production and vascular relaxation.
• Supports arterial compliance, endothelial function, and circulatory health.
  

TG3 Heart Support is suited for integrative approaches to managing hypertension, atherosclerosis, and vascular inflammation, particularly when paired with lifestyle and dietary interventions.

Qmega-TG3™: Ultra-Pure Omega-3 Triglyceride Form

Qmega-TG3™ delivers highly concentrated EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) in their re-esterified triglyceride (rTG) form, which offers superior absorption and tolerability compared to ethyl ester forms. Each softgel is third-party tested for purity, potency, and oxidative stability.

Key Features:

• Re-esterified triglyceride form offers up to 70% greater absorption than ethyl ester omega-3s.
• Sourced from sustainably harvested cold-water fish, molecularly distilled for purity and toxin-free assurance.
• Provides clinically relevant doses of EPA and DHA, supporting lipid balance, inflammatory control, cognitive function, and cardiac health.
• Ideal for use in patients with dyslipidemia, inflammatory conditions, or elevated cardiovascular risk.
  
  

Qmega-TG3 exemplifies TruGen3’s dedication to clean-label, high-potency fish oil therapy supported by clinical evidence and advanced delivery form.

Together, these three products represent TruGen3’s formulation ethos: combining the highest quality ingredients, advanced absorption systems, and condition-specific applications to provide healthcare practitioners with tools that produce measurable results in cardiovascular and metabolic health.

Conclusion: Building the Future of Nutraceutical Truth

TruGen3 is not just another supplement company—it is the embodiment of a philosophy that prizes truth, science, and patient-centric innovation above all else.

By focusing on doctor-formulated, evidence-based supplements enhanced with the best branded ingredients and advanced delivery technologies, TruGen3 has earned its place as a leading name among healthcare professionals seeking to optimize patient health outcomes.

As the world of integrative and functional medicine continues to grow, TruGen3 remains steadfast in its mission to deliver clinical truth for a new generation—one practitioner, one patient, and one success story at a time.