Endourage, LLC: Advancing ECS Health Through Full-Spectrum Botanical Innovation

In the evolving world of functional and integrative medicine, few companies address inflammation and chronic disease as directly and effectively as Endourage, LLC. Founded in 2018, Endourage merges two foundational concepts—the Endocannabinoid System (ECS) and the entourage effect—to deliver full-spectrum, physician-recommended formulations that restore metabolic balance and improve chronic health outcomes.

The company name itself reflects its mission: replacing the “t” in “entourage” with a “d” signals a deliberate focus on the endocannabinoid system, which Endourage targets through synergistic blends of phytocannabinoids, terpenes, and flavonoids.

Endourage’s mission is to restore ECS function with research-backed, full-spectrum phytocannabinoid formulations that contain active compounds in synergistic ratios—rather than relying on single-molecule isolates like CBD alone.

The Endocannabinoid System: Homeostasis Through Synergy

The ECS is the master regulator of homeostasis, orchestrating balance across every physiological system. When the body experiences stress, inflammation, or pain, the ECS modulates the response by producing endocannabinoids that interact with specific receptors to restore equilibrium.

However, when the ECS becomes dysregulated—due to chronic stress, inflammation, poor nutrition, or excessive medication—its ability to maintain homeostasis is compromised. This contributes to widespread chronic conditions such as fatigue, anxiety, depression, obesity, pain, and sleep disturbances.

Product Philosophy: The Power of the Full Spectrum

Endourage’s approach begins with the belief that healing the ECS requires complete molecular diversity. Each product includes a full-spectrum blend of:

Phytocannabinoids (e.g., CBD, CBG, CBDV)
Terpenes, which deliver potent medicinal effects and enhance cannabinoid activity
Flavonoids, which offer additional anti-inflammatory and antioxidant benefits

Unlike high-dose isolate products, Endourage’s formulations are designed to act synergistically—maximizing efficacy while minimizing or negating side effects. The terpenes, though fragile, are preserved through advanced extraction methods to ensure their full therapeutic contribution.

“The ECS is like a multi-lock, multi-key system,” explains Chief Medical Officer Dr. Michael Steward. “A single cannabinoid like CBD might unlock one lock—but the full spectrum of locks is needed to fully restore balance.”

Evidence-Based Origins: From Long COVID to Chronic Disease

Endourage began its rise during the early stages of the COVID-19 pandemic. In 2020, Dr. Steward hypothesized that a terpene-rich, full-spectrum cannabinoid formulation could safely reduce symptoms associated with Long COVID—such as inflammation, anxiety, pain, sleep disruption, and fatigue.

The results were striking: clinical data showed symptom improvement in 9 of 9 target areas after 28 days, with no significant adverse effects. These findings, later validated in subsequent trials, fueled the development of additional Endourage formulations for chronic conditions.

Today, Endourage continues to expand its human trial research, publishing in medical journals and collaborating with clinicians to target inflammation-linked diseases like depression, anxiety, addiction, pain management, and fatigue.

Practitioner-First Model: Safe, Natural, and Clinically Supported

Endourage products are dispensed and available exclusively through healthcare providers, including physicians, functional medicine doctors, and integrative practitioners. Key advantages include:

Clinician support via training, clinical guides, and concierge services
Safe, adjunctive use with no intoxicating or habit-forming risk
Label transparency, listing all active ingredients and referencing published studies
Access to discounted patient pricing via practitioner recommendation
Ongoing FDA botanical drug development, with 8+ formulations targeted for approval

"Clinicians trust Endourage because it is so evidence-driven and ECS-focused—Endourage is academically and clinically vetted and recommended…it is not hype or high-dose CBD," notes CRO Chris Lundwall. He adds, “Most residents and clinicians we deliver ECS medical training to are surprised to learn about the research is that more than 400 molecules work synergistically with the ECS, and CBD is just one of those molecules, so expecting CBD alone without a full spectrum of cannabinoids and terpenes in specific ratios and concentrations to restore ECS regulation of inflammation-driven chronic conditions is a bit like buying a car and just receiving a rear axle…you may be able to balance on the axle and learn to barrel-walk yourself around town, but what you really paid for was a complete car that would comfortably and safely provide you and yours with reliable all-weather transportation.”

Product Highlights

Formula C

Originally developed to support patients with Long COVID, Formula C is a full-spectrum formulation shown to attenuate inflammation, anxiety, depression, sleep disturbance, fatigue, and pain..

Targeted ECS upregulation with simple dosing recommendations
Clinician-recommended nationwide to improve any or all of the studied symptoms
Cited in multiple medical journals and no significant adverse side effects reported

Link to Endourage Public Research:

Notes for Recommending Clinicians: Clinicians are encouraged when making product recommendations to advise patients with phytocannabinoid policies to first contact their human resources personnel with related questions. Patients can enlist the support of their clinician for appropriate and necessary exemptions. Patients with histories of being highly sensitive to medications should be encouraged to start with modest drops-first dosing that is titrated up to normal dropper-based doses. Clinicians recommending sublingual products should take note of patients with allergies to pinene, MCT/coconuts, and in the case of Verasome, aloe vera. When evaluating Endourage products as adjunctive therapeutics, clinicians can search “hemp” in their preferred drug-drug interactions website. While Endourage products are recommended rather than prescribed, clinicians can encourage patients to use their HSA and/or FSA for Endourage purchases. Endourage can always be reached by clinicians at info@endourage.com or contacted by phone at 855 920 7546 and they will be directed to the clinician concierge team for a prompt response.

Verasome

An advanced topical delivery system enhancing bioavailability and clinical potency across a broad range of inflammation conditions on the skin or in the soft tissue.
• Terpene-rich analgesic and anti-inflammation formulation designed with Dr Byron Jones, M.D. to improve range of motion; increasingly used by rehabilitation hospitals and physical therapy clinics as a safe, natural and superior alternative to various biofreeze and corticosteroid products

Key Verasome Terpenes: beta-Caryohyllene, alpha-Humuline, Guaiol, Caryophyllene Oxide, alpha-Bisabolol

Ideal for musculoskeletal flare-ups, neuropathy arthritis, rheumatoid arthritis, joint pain, and physical therapy/physical rehabilitation integration and pre-post athletic training care.
Onset commonly reported to be less than 10 minutes; applied as needed; no significant adverse effects reported by clinicians
Also available in 1 Liter size for high volume clinic use. Keep refrigerated/at or below room temp.

Formula ZZZ

A non-sedating botanical formulation supporting restful sleep through ECS modulation and circadian rhythm support.

Combines phytocannabinoids and terpenes specific to sleep regulation
Ideal for patients seeking sleep hygiene to address chronic insomnia, anxiety, or nighttime inflammation
No significant adverse side effects reported; patients report waking well rested without any drowsiness; Some Whoop users anecdotally report observing overall sleep scores improve ~20% when using ZZZ.

Formula AX

Non-addictive and adjunctive formulation designed to attenuate anxiety.

Rich in terpenes with anxiolytic and anti-inflammation properties
Ideal for patients managing chronic or intermittent anxiety; also recommended for those patients pre-emptively approaching events that may trigger their anxiety (e.g. public speaking, air travel, large gatherings, etc.)

Looking Ahead: Clinical Innovation and Expanded Access

Endourage is poised to lead the ECS wellness revolution. With expanding R&D, new formulations, and plans to bring multiple products through the FDA botanical drug pathway, Endourage is working to:

Reduce chronic disease and inflammation via improved ECS health
Improve insurance access to safe ECS therapies
Deliver global distribution to clinicians worldwide
Continue publishing peer-reviewed data on chronic disease outcomes

By pairing clinical rigor with botanical integrity, Endourage delivers what both patients and practitioners demand: effective, research-driven tools to fight inflammation and chronic disease—without adverse effects.

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